Cell Senescence-associated Genes

Found 165 results. Showing results 1 to 20.

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Gene Name Method Cell Types Cell Lines Cancer Cell Line? Senescence Type Senescence Effect
AAK1OverexpressionLung fibroblast, Embryonic kidneyIMR-90, MRC-5, HEK293TNoReplicativePromotes
ABI3OverexpressionThyroid cancer, Colon cancerWRO, AROYesReplicativePromotes
ADCK5OverexpressionEmbryonic kidney, Lung fibroblastIMR-90, MRC-5, HEK293TNoReplicativePromotes
AGTOverexpression, KnockoutVascular smooth musclePrimary cellNoReplicativePromotes
AKR1B1Overexpression, KnockdownKeratinocyteHaCatYesStress-inducedInhibits
AKT1OverexpressionAortic endothelial, Umbilical vein endothelial, Dermal microvascular endothelial cellsPrimary cellNoOncogene-inducedPromotes
ALOX15BOverexpressionProstate epithelialPrimary cellNoReplicativePromotes
AROverexpression, KnockdownHair follicular keratinocytePrimary cellNoReplicativePromotes
ARPC1BOverexpressionOsteosarcomaSaOs-2YesReplicativePromotes
ASF1AKnockout, OverexpressionLung fibroblastPrimary cellNoReplicative, Oncogene-inducedPromotes
AXLOverexpressionLung fibroblast, Embryonic kidneyIMR-90, MRC-5, HEK293TNoReplicativePromotes
BCL6OverexpressionB-cellPrimary cellNoReplicativeInhibits
BHLHE40OverexpressionEsophageal cancer, Breast cancerEC9706, MCF-7YesStress-induced, ReplicativePromotes
BLKOverexpressionEmbryonic kidney, Lung fibroblastIMR-90, MRC-5, HEK293TNoReplicativePromotes
BMI1Knockout, OverexpressionForeskin fibroblast, Lung fibroblast, Skin fibroblastWI-38, BJ, 82-6NoReplicativeInhibits
BRAFOverexpressionForeskin fibroblast, MelanocytePrimary cell, BJNoOncogene-inducedPromotes
CBX7Overexpression, KnockdownLung fibroblast, KeratinocyteWI-38, Primary cellNoReplicativeInhibits
CBX8OverexpressionFibroblastTIG-3NoReplicativeInhibits
CCND1OverexpressionFibroblastWI-38, Hs68NoReplicativePromotes
CDK18OverexpressionEmbryonic kidney, Lung fibroblastIMR-90, MRC-5, HEK293TNoReplicativePromotes