Cell Senescence-associated Genes

Found 43 results. Showing results 1 to 20.

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Gene Name Method Cell Types Cell Lines Cancer Cell Line? Senescence Type Senescence Effect
ACLYKnockoutDermal fibroblastPrimary cellNoReplicativeInhibits
AGTKnockout, OverexpressionVascular smooth musclePrimary cellNoReplicativePromotes
ASF1AKnockout, OverexpressionLung fibroblastPrimary cellNoOncogene-induced, ReplicativePromotes
ATMKnockoutForeskin fibroblast, Lung fibroblastBJ, MRC-5, WI-38NoReplicativeInhibits
BMI1Knockout, OverexpressionForeskin fibroblast, Lung fibroblast, Skin fibroblast82-6, BJ, WI-38NoReplicativeInhibits
CDKN1AKnockoutFibroblastLF1NoReplicativePromotes
CHEK1KnockoutColon cancerHCT116YesStress-inducedPromotes
CPEB1Knockout, OverexpressionForeskin fibroblast, Lung fibroblastPrimary cell, WI-38NoReplicativePromotes
DDB2KnockoutLung fibroblastIMR-90NoOncogene-inducedPromotes
DPY30KnockoutLung fibroblastIMR-90NoReplicativeInhibits
EWSR1KnockoutHematopoietic stemPrimary cellNoReplicativePromotes
G6PDKnockoutForeskin fibroblastPrimary cellNoReplicativeInhibits
GNG11Knockout, OverexpressionLung fibroblastTIG-7NoReplicativePromotes
HDAC4Knockout, OverexpressionLung fibroblast2BSNoReplicativeInhibits
HSPA5Knockout, OverexpressionOvarian cancerA2780YesStress-inducedInhibits
IGFBP5Knockout, OverexpressionUmbilical vein endothelialPrimary cellNoReplicativePromotes
IL1AKnockoutUmbilical vein endothelialPrimary cellNoReplicativePromotes
ING2Knockout, OverexpressionLung fibroblastMRC-5NoReplicativePromotes
KCNJ12KnockoutBreast cancer, Gastric cancer, Prostate cancerDU145, LNCaP, MCF-7, MKN74, PC-3, SK-BR3, SNU-484, SNU-638, SNU-668, T47DYesStress-inducedInhibits
MAPK14KnockoutLung fibroblastMRC-5, WI-38NoReplicative, Stress-inducedPromotes