Cell Senescence-associated Genes

Found 43 results. Showing results 1 to 20.

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Gene Name Method Cell Types Cell Lines Cancer Cell Line? Senescence Type Senescence Effect
ACLYKnockoutDermal fibroblastPrimary cellNoReplicativeInhibits
AGTOverexpression, KnockoutVascular smooth musclePrimary cellNoReplicativePromotes
ASF1AKnockout, OverexpressionLung fibroblastPrimary cellNoReplicative, Oncogene-inducedPromotes
ATMKnockoutForeskin fibroblast, Lung fibroblastMRC-5, WI-38, BJNoReplicativeInhibits
BMI1Knockout, OverexpressionForeskin fibroblast, Lung fibroblast, Skin fibroblastWI-38, BJ, 82-6NoReplicativeInhibits
CDKN1AKnockoutFibroblastLF1NoReplicativePromotes
CHEK1KnockoutColon cancerHCT116YesStress-inducedPromotes
CPEB1Overexpression, KnockoutLung fibroblast, Foreskin fibroblastPrimary cell, WI-38NoReplicativePromotes
DDB2KnockoutLung fibroblastIMR-90NoOncogene-inducedPromotes
DPY30KnockoutLung fibroblastIMR-90NoReplicativeInhibits
EWSR1KnockoutHematopoietic stemPrimary cellNoReplicativePromotes
G6PDKnockoutForeskin fibroblastPrimary cellNoReplicativeInhibits
GNG11Overexpression, KnockoutLung fibroblastTIG-7NoReplicativePromotes
HDAC4Overexpression, KnockoutLung fibroblast2BSNoReplicativeInhibits
HSPA5Overexpression, KnockoutOvarian cancerA2780YesStress-inducedInhibits
IGFBP5Overexpression, KnockoutUmbilical vein endothelialPrimary cellNoReplicativePromotes
IL1AKnockoutUmbilical vein endothelialPrimary cellNoReplicativePromotes
ING2Overexpression, KnockoutLung fibroblastMRC-5NoReplicativePromotes
KCNJ12KnockoutProstate cancer, Breast cancer, Gastric cancerPC-3, DU145, LNCaP, MKN74, SNU-484, SNU-638, SNU-668, MCF-7, SK-BR3, T47DYesStress-inducedInhibits
MAPK14KnockoutLung fibroblastWI-38, MRC-5NoStress-induced, ReplicativePromotes