Cell Senescence Entries for ACLY

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
ACLY knockdown in primary human cells triggered cellular senescence and activation of tumor suppressor p53. Provision of acetyl CoA to ACLY knockdown cells did not alleviate ACLY silencing-induced p53 activation, suggesting an independent role for ACLY activity.
Primary Reference

    ACLY Gene Information

    HGNC symbol
    ACLY 
    Aliases
    ACL; ATPCL; CLATP 
    Common name
    ATP citrate lyase 
    Entrez Id
    47
    Description
    ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

    ACLY Ontologies

    Gene Ontology
    Process: GO:6085; acetyl-CoA biosynthetic process
    GO:6695; cholesterol biosynthetic process
    GO:6101; citrate metabolic process
    GO:6633; fatty acid biosynthetic process
    GO:8610; lipid biosynthetic process
    GO:35338; long-chain fatty-acyl-CoA biosynthetic process
    GO:43312; neutrophil degranulation
    GO:6107; oxaloacetate metabolic process
    GO:31325; positive regulation of cellular metabolic process
    Cellular component: GO:35578; azurophil granule lumen
    GO:9346; citrate lyase complex
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5576; extracellular region
    GO:1904813; ficolin-1-rich granule lumen
    GO:16020; membrane
    GO:5654; nucleoplasm
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:3878; ATP citrate synthase activity
    GO:48037; cofactor binding
    GO:46872; metal ion binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of ACLY in Model Organisms

    Caenorhabditis elegans
    acly-2
    Danio rerio
    aclya
    Drosophila melanogaster
    ATPCL
    Mus musculus
    Acly
    Rattus norvegicus
    Acly
    Schizosaccharomyces pombe
    SPBC1703.07

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as ATPCL
    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Acly

    External links

    OMIM
    108728
    Ensembl
    ENSG00000131473
    Entrez Gene
    47
    UniGene
    387567
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ACLY
    GeneCards
    ACLY