Cell Senescence Entries for ABI3

Cell Types
Thyroid cancer, Colon cancer
Cell Lines
WRO, ARO
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Ectopic expression of ABI3 lowered transforming activity, reduced in vitro tumor growth properties, suppressed in vitro anchorage-independent growth and in vivo tumor formation, whilst also increasing cellular senescence. These responses were accompanied by upregulation of cell cycle inhibitor p21 and reduced ERK phosphorylation and E2F1 expression.
Primary Reference

    ABI3 Gene Information

    HGNC symbol
    ABI3 
    Aliases
    NESH; SSH3BP3 
    Common name
    ABI family member 3 
    Entrez Id
    51225
    Description
    This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

    ABI3 Ontologies

    Gene Ontology
    Process: GO:6928; movement of cell or subcellular component
    GO:18108; peptidyl-tyrosine phosphorylation
    GO:30334; regulation of cell migration
    Cellular component: GO:5737; cytoplasm
    GO:5622; intracellular
    GO:30027; lamellipodium
    GO:16020; membrane
    Function: GO:42802; identical protein binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of ABI3 in Model Organisms

    Mus musculus
    Abi3
    Rattus norvegicus
    Abi3

    External links

    OMIM
    606363
    Ensembl
    ENSG00000108798
    Entrez Gene
    51225
    UniGene
    130719
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ABI3
    GeneCards
    ABI3