Cell Senescence Entries for AGT

Cell Types
Vascular smooth muscle
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression, Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Treatment with Ang II (AGT) of vascular smooth muscle cells significantly induced premature senescence (including increased SA-beta galactosidase activity) via the p53/p21-dependent pathway.
Primary Reference

    AGT Gene Information

    HGNC symbol
    AGT 
    Aliases
    ANHU; hFLT1; SERPINA8 
    Common name
    angiotensinogen 
    Entrez Id
    183
    Description
    The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

    AGT Ontologies

    Gene Ontology
    Process: GO:70371; ERK1 and ERK2 cascade
    GO:7186; G-protein coupled receptor signaling pathway
    GO:7199; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
    GO:7202; activation of phospholipase C activity
    GO:7568; aging
    GO:2003; angiotensin maturation
    GO:3051; angiotensin-mediated drinking behavior
    GO:14824; artery smooth muscle contraction
    GO:1974; blood vessel remodeling
    GO:35411; catenin import into nucleus
    GO:61049; cell growth involved in cardiac muscle cell development
    And 70 more GO terms
    Cellular component: GO:72562; blood microparticle
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5576; extracellular region
    GO:5615; extracellular space
    Function: GO:8083; growth factor activity
    GO:5179; hormone activity
    GO:5515; protein binding
    GO:4867; serine-type endopeptidase inhibitor activity
    GO:31702; type 1 angiotensin receptor binding
    GO:31703; type 2 angiotensin receptor binding
    Show all GO terms

    Homologs of AGT in Model Organisms

    Danio rerio
    agt
    Mus musculus
    Agt
    Rattus norvegicus
    Agt

    In other databases

    LongevityMap
    • This gene is present as AGT

    External links

    OMIM
    106150
    Ensembl
    ENSG00000135744
    Entrez Gene
    183
    UniGene
    19383
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    AGT
    GeneCards
    AGT