Cell Senescence Entries for ZNF148

Cell Types
Lung cancer
Cell Lines
NCI-H460
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
In human lung cancer cells RNA interference of ZBP-89 (ZNF148) stimulated cellular senescence, with cells displaying an increase in SA-beta-galactosidase activity and SA-heterochromatin foci.
Primary Reference

    ZNF148 Gene Information

    HGNC symbol
    ZNF148 
    Aliases
    BERF-1; BFCOL1; GDACCF; ZBP-89; ZFP148; pHZ-52; HT-BETA 
    Common name
    zinc finger protein 148 
    Entrez Id
    7707
    Description
    The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]

    ZNF148 Ontologies

    Gene Ontology
    Process: GO:6968; cellular defense response
    GO:7276; gamete generation
    GO:10629; negative regulation of gene expression
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:45892; negative regulation of transcription, DNA-templated
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:6461; protein complex assembly
    GO:21762; substantia nigra development
    GO:6366; transcription from RNA polymerase II promoter
    Cellular component: GO:5794; Golgi apparatus
    GO:5634; nucleus
    Function: GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:46872; metal ion binding
    GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    GO:1078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of ZNF148 in Model Organisms

    Danio rerio
    znf148
    Mus musculus
    Znf148
    Rattus norvegicus
    Znf148

    External links

    OMIM
    601897
    Ensembl
    ENSG00000163848
    Entrez Gene
    7707
    UniGene
    592591
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ZNF148
    GeneCards
    ZNF148