Cell Senescence Entries for ZMAT3

Cell Types
Dermal fibroblast, Breast cancer, Osteosarcoma, Embryonic kidney
Cell Lines
MCF-7, HEK293T, U2OS
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Depletion of Wig1 (ZMAT3) prohibited miRNA-mediated p21 mRNA decay and resulted in premature senescence.
Primary Reference

    ZMAT3 Gene Information

    HGNC symbol
    ZMAT3 
    Aliases
    WIG1; WIG-1; PAG608 
    Common name
    zinc finger matrin-type 3 
    Entrez Id
    64393
    Description
    This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

    ZMAT3 Ontologies

    Gene Ontology
    Process: GO:6974; cellular response to DNA damage stimulus
    GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator
    GO:43065; positive regulation of apoptotic process
    GO:15031; protein transport
    GO:40008; regulation of growth
    Cellular component: GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5886; plasma membrane
    Function: GO:3723; RNA binding
    GO:2039; p53 binding
    GO:5515; protein binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of ZMAT3 in Model Organisms

    Danio rerio
    BX548160.2
    Mus musculus
    Zmat3
    Rattus norvegicus
    Zmat3

    External links

    OMIM
    606452
    Ensembl
    ENSG00000172667
    Entrez Gene
    64393
    UniGene
    371609
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ZMAT3
    GeneCards
    ZMAT3