Cell Senescence Entries for ZFP36

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Expression of TTP (ZFP36) in HeLA cells resulted in a marked reduction in proliferation, a flattened morphology resembling that of replicative senescence and upon longer exposure to TTP, elevated levels of SA-beta-galactosidase .
Primary Reference

    ZFP36 Gene Information

    HGNC symbol
    ZFP36 
    Aliases
    TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A 
    Common name
    ZFP36 ring finger protein 
    Entrez Id
    7538
    Description

    ZFP36 Ontologies

    Gene Ontology
    Process: GO:61158; 3'-UTR-mediated mRNA destabilization
    GO:70935; 3'-UTR-mediated mRNA stabilization
    GO:165; MAPK cascade
    GO:71364; cellular response to epidermal growth factor stimulus
    GO:44344; cellular response to fibroblast growth factor stimulus
    GO:71385; cellular response to glucocorticoid stimulus
    GO:97011; cellular response to granulocyte macrophage colony-stimulating factor stimulus
    GO:71222; cellular response to lipopolysaccharide
    GO:71356; cellular response to tumor necrosis factor
    GO:6402; mRNA catabolic process
    GO:51028; mRNA transport
    And 24 more GO terms
    Cellular component: GO:30014; CCR4-NOT complex
    GO:98745; Dcp1-Dcp2 complex
    GO:932; P-body
    GO:70578; RISC-loading complex
    GO:5737; cytoplasm
    GO:10494; cytoplasmic stress granule
    GO:5829; cytosol
    GO:178; exosome (RNase complex)
    GO:30529; intracellular ribonucleoprotein complex
    GO:5634; nucleus
    GO:1990904; ribonucleoprotein complex
    And 1 more GO terms
    Function: GO:71889; 14-3-3 protein binding
    GO:17091; AU-rich element binding
    GO:19957; C-C chemokine binding
    GO:3677; DNA binding
    GO:3723; RNA binding
    GO:70063; RNA polymerase binding
    GO:19899; enzyme binding
    GO:31072; heat shock protein binding
    GO:35925; mRNA 3'-UTR AU-rich region binding
    GO:3729; mRNA binding
    GO:46872; metal ion binding
    And 4 more GO terms
    Show all GO terms

    Homologs of ZFP36 in Model Organisms

    Caenorhabditis elegans
    ccch-1
    Mus musculus
    Zfp36
    Rattus norvegicus
    Zfp36

    External links

    OMIM
    190700
    Ensembl
    ENSG00000128016
    Entrez Gene
    7538
    UniGene
    534052
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    ZFP36
    GeneCards
    ZFP36