Cell Senescence Entries for YAP1
- Cell Types
- Foreskin fibroblast, Lung fibroblast
- Cell Lines
- BJ, IMR-90, WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- Silencing of YAP1 inhibited cell proliferation and induced premature senescence. In additional experiments, it was shown that cellular senescence induced by YAP1 deficiency is TEAD- and Rb/p16/p53-dependent.
- Primary Reference
YAP1 Gene Information
- HGNC symbol
- YAP1
- Aliases
- YAP; YKI; COB1; YAP2; YAP65
- Common name
- Yes associated protein 1
- Entrez Id
- 10413
- Description
- This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
YAP1 Ontologies
- Gene Ontology
-
Process: GO:60449; bud elongation involved in lung branching
GO:902; cell morphogenesis
GO:8283; cell proliferation
GO:6974; cellular response to DNA damage stimulus
GO:71480; cellular response to gamma radiation
GO:71300; cellular response to retinoic acid
GO:60242; contact inhibition
GO:3143; embryonic heart tube morphogenesis
GO:35329; hippo signaling
GO:30216; keratinocyte differentiation
GO:48368; lateral mesoderm development
And 22 more GO terms Cellular component: GO:71148; TEAD-1-YAP complex
GO:71149; TEAD-2-YAP complex
GO:5737; cytoplasm
GO:5829; cytosol
GO:16020; membrane
GO:5654; nucleoplasm
GO:5634; nucleus
Function: GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:33613; activating transcription factor binding
GO:3682; chromatin binding
GO:70064; proline-rich region binding
GO:8022; protein C-terminus binding
GO:5515; protein binding
GO:46982; protein heterodimerization activity
GO:3713; transcription coactivator activity
GO:3714; transcription corepressor activity
GO:1076; transcription factor activity, RNA polymerase II transcription factor binding
GO:44212; transcription regulatory region DNA binding
And 1 more GO terms
Homologs of YAP1 in Model Organisms
External links
- OMIM
- 606608
- Ensembl
- ENSG00000137693
- Entrez Gene
- 10413
- UniGene
- 503692
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- YAP1
- GeneCards
- YAP1