Cell Senescence Entries for YAP1

Cell Types
Lung fibroblast, Foreskin fibroblast
Cell Lines
IMR-90, WI-38, BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Silencing of YAP1 inhibited cell proliferation and induced premature senescence. In additional experiments, it was shown that cellular senescence induced by YAP1 deficiency is TEAD- and Rb/p16/p53-dependent.
Primary Reference

    YAP1 Gene Information

    HGNC symbol
    YAP1 
    Aliases
    YAP; YKI; COB1; YAP2; YAP65 
    Common name
    Yes associated protein 1 
    Entrez Id
    10413
    Description
    This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

    YAP1 Ontologies

    Gene Ontology
    Process: GO:60449; bud elongation involved in lung branching
    GO:902; cell morphogenesis
    GO:8283; cell proliferation
    GO:6974; cellular response to DNA damage stimulus
    GO:71480; cellular response to gamma radiation
    GO:71300; cellular response to retinoic acid
    GO:60242; contact inhibition
    GO:3143; embryonic heart tube morphogenesis
    GO:35329; hippo signaling
    GO:30216; keratinocyte differentiation
    GO:48368; lateral mesoderm development
    And 22 more GO terms
    Cellular component: GO:71148; TEAD-1-YAP complex
    GO:71149; TEAD-2-YAP complex
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:16020; membrane
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:979; RNA polymerase II core promoter sequence-specific DNA binding
    GO:33613; activating transcription factor binding
    GO:3682; chromatin binding
    GO:70064; proline-rich region binding
    GO:8022; protein C-terminus binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    GO:3713; transcription coactivator activity
    GO:3714; transcription corepressor activity
    GO:1076; transcription factor activity, RNA polymerase II transcription factor binding
    GO:44212; transcription regulatory region DNA binding
    And 1 more GO terms
    Show all GO terms

    Homologs of YAP1 in Model Organisms

    Danio rerio
    yap1
    Mus musculus
    Yap1
    Rattus norvegicus
    Yap1

    External links

    OMIM
    606608
    Ensembl
    ENSG00000137693
    Entrez Gene
    10413
    UniGene
    503692
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    YAP1
    GeneCards
    YAP1