Cell Senescence Entries for XAF1

Cell Types
Dermal microvascular endothelial cells
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression, Knockdown
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
XAF1 expression was increased by genotoxic agents, such as doxorubicin and ionizing radiation in pulmonary microvascular endothelial cells, consequently leading to premature senescence. Conversely, downregulation of XAF1 in premature senescent cells partially overcame endothelial cell senescence. p53 knockdown, but not p16 knockdown, abolished senescence phenotypes caused by XAF1 induction. XAF1 expression was transcriptionally regulated by Bromodomain 7 (BRD7). XAF1 induction with interferon-gamma (IFN-gamma) treatment was abrogated by BRD7 knockdown, which resulted in blocking interferon-induced senescence.
Primary Reference

    XAF1 Gene Information

    HGNC symbol
    XAF1 
    Aliases
    BIRC4BP; XIAPAF1; HSXIAPAF1 
    Common name
    XIAP associated factor 1 
    Entrez Id
    54739
    Description
    This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

    XAF1 Ontologies

    Gene Ontology
    Process: GO:6915; apoptotic process
    GO:31333; negative regulation of protein complex assembly
    GO:35456; response to interferon-beta
    GO:60337; type I interferon signaling pathway
    Cellular component: GO:5829; cytosol
    GO:5739; mitochondrion
    GO:5634; nucleus
    Function: GO:8270; zinc ion binding
    Show all GO terms

    Homologs of XAF1 in Model Organisms

    Mus musculus
    Xaf1
    Rattus norvegicus
    XAF1

    External links

    OMIM
    606717
    Ensembl
    ENSG00000132530
    Entrez Gene
    54739
    UniGene
    441975
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    XAF1
    GeneCards
    XAF1