Cell Senescence Entries for WWP1

Cell Types
Lung fibroblast
Cell Lines
WI-38, 2BS
Cancer Cell?
No
Method
Overexpression, Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Overexpression of WWP1 delayed senescence, whereas knockdown of WWP1 led to premature senescence in human fibroblasts.
Primary Reference

    WWP1 Gene Information

    HGNC symbol
    WWP1 
    Aliases
    AIP5; Tiul1; hSDRP1 
    Common name
    WW domain containing E3 ubiquitin protein ligase 1 
    Entrez Id
    11059
    Description
    WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

    WWP1 Ontologies

    Gene Ontology
    Process: GO:7417; central nervous system development
    GO:34220; ion transmembrane transport
    GO:45892; negative regulation of transcription, DNA-templated
    GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
    GO:16567; protein ubiquitination
    GO:7165; signal transduction
    GO:46718; viral entry into host cell
    Cellular component: GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:151; ubiquitin ligase complex
    Function: GO:5515; protein binding
    GO:61630; ubiquitin protein ligase activity
    GO:4842; ubiquitin-protein transferase activity
    Show all GO terms

    Homologs of WWP1 in Model Organisms

    Mus musculus
    Wwp1
    Rattus norvegicus
    Wwp1

    External links

    OMIM
    602307
    Ensembl
    ENSG00000123124
    Entrez Gene
    11059
    UniGene
    655189
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    WWP1
    GeneCards
    WWP1