Cell Senescence Entries for WT1

Cell Types
Lung cancer
Cell Lines
NCI-H1568, NCI-H23, NCI-H522, NCI-H1437, NCI-H1650, NCI-H1975, NCI-H2126, NCI-H358, NCI-H441, NCI-H460, NCI-H727, NCI-H1299, NCI-H2009, NCI-A549
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Observations
Loss of Wilms Tumor 1 (WT1) in human lung cancer cells dependent on oncogenic KRAS resulted in reduced proliferation and induced senescence, thus shifting cell fate from hyperproliferation to oncogene-induced senescence.
Primary Reference

    WT1 Gene Information

    HGNC symbol
    WT1 
    Aliases
    GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1 
    Common name
    Wilms tumor 1 
    Entrez Id
    7490
    Description
    This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

    WT1 Ontologies

    Gene Ontology
    Process: GO:8380; RNA splicing
    GO:35802; adrenal cortex formation
    GO:30325; adrenal gland development
    GO:1658; branching involved in ureteric bud morphogenesis
    GO:43010; camera-type eye development
    GO:60923; cardiac muscle cell fate commitment
    GO:71320; cellular response to cAMP
    GO:71371; cellular response to gonadotropin stimulus
    GO:60539; diaphragm development
    GO:30855; epithelial cell differentiation
    GO:7281; germ cell development
    And 36 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:16607; nuclear speck
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:70742; C2H2 zinc finger domain binding
    GO:3723; RNA binding
    GO:10385; double-stranded methylated DNA binding
    GO:44729; hemi-methylated DNA-binding
    GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:44212; transcription regulatory region DNA binding
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of WT1 in Model Organisms

    Danio rerio
    wt1a
    Mus musculus
    Wt1
    Rattus norvegicus
    Wt1
    Schizosaccharomyces pombe
    SPAC25B8.19c

    External links

    OMIM
    607102
    Ensembl
    ENSG00000184937
    Entrez Gene
    7490
    UniGene
    591980
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    WT1
    GeneCards
    WT1