Cell Senescence Entries for WNT2

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
RNA interference of WNT2 in young, growing human WI-38 fibroblasts, lead to a partially senescence phenotype, including recruitment of chaperone HIRA to PML bodies, formation of SA-heterochromatin foci and increased SA-beta-galactosidase activity but no changes in morphology.
Primary Reference

    WNT2 Gene Information

    HGNC symbol
    WNT2 
    Aliases
    IRP; INT1L1 
    Common name
    Wnt family member 2 
    Entrez Id
    7472
    Description
    This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

    WNT2 Ontologies

    Gene Ontology
    Process: GO:16055; Wnt signaling pathway
    GO:55009; atrial cardiac muscle tissue morphogenesis
    GO:60070; canonical Wnt signaling pathway
    GO:1904954; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
    GO:60317; cardiac epithelial to mesenchymal transition
    GO:45165; cell fate commitment
    GO:33278; cell proliferation in midbrain
    GO:7267; cell-cell signaling
    GO:71300; cellular response to retinoic acid
    GO:71560; cellular response to transforming growth factor beta stimulus
    GO:61072; iris morphogenesis
    And 19 more GO terms
    Cellular component: GO:1990909; Wnt signalosome
    GO:5737; cytoplasm
    GO:31012; extracellular matrix
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:5886; plasma membrane
    GO:5578; proteinaceous extracellular matrix
    Function: GO:5125; cytokine activity
    GO:5109; frizzled binding
    GO:5515; protein binding
    GO:48018; receptor agonist activity
    Show all GO terms

    Homologs of WNT2 in Model Organisms

    Mus musculus
    Wnt2
    Rattus norvegicus
    Wnt2

    External links

    OMIM
    147870
    Ensembl
    ENSG00000105989
    Entrez Gene
    7472
    UniGene
    567356
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    WNT2
    GeneCards
    WNT2