Cell Senescence Entries for WNT16

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
RNA interference of WNT16B increased the replicative potential of presenescent lung fibroblasts.
Primary Reference

    WNT16 Gene Information

    HGNC symbol
    WNT16 
    Aliases
     
    Common name
    Wnt family member 16 
    Entrez Id
    51384
    Description
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]

    WNT16 Ontologies

    Gene Ontology
    Process: GO:16055; Wnt signaling pathway
    GO:46849; bone remodeling
    GO:60317; cardiac epithelial to mesenchymal transition
    GO:45165; cell fate commitment
    GO:30216; keratinocyte differentiation
    GO:43616; keratinocyte proliferation
    GO:60548; negative regulation of cell death
    GO:30182; neuron differentiation
    GO:3408; optic cup formation involved in camera-type eye development
    GO:90403; oxidative stress-induced premature senescence
    GO:46330; positive regulation of JNK cascade
    And 4 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:5578; proteinaceous extracellular matrix
    Function: GO:5109; frizzled binding
    Show all GO terms

    Homologs of WNT16 in Model Organisms

    Caenorhabditis elegans
    egl-20
    Danio rerio
    wnt16
    Mus musculus
    Wnt16
    Rattus norvegicus
    Wnt16

    External links

    OMIM
    606267
    Ensembl
    ENSG00000002745
    Entrez Gene
    51384
    UniGene
    272375
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    WNT16
    GeneCards
    WNT16