Cell Senescence Entries for VENTX

Cell Types
Embryonic kidney, Osteosarcoma, Lung fibroblast, Cervical cancer, Lymphoblastic leukemia
Cell Lines
HEK293T, HeLa, U2OS, Nalm16, IMR-90
Cancer Cell?
Yes
Method
Overexpression, Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Ectopic expression of VENTX in cancer cells (U2OS and HeLa) caused an irreversible cell cycle arrest with a typical senescence-like phenotype. Conversely, RNA interference of VentX reduces chemotherapeutic agent-induced senescence in lymphocytic leukaemia cells. In normal lung fibroblasts, overexpression of VentX also caused a typical senescence phenotype.
Primary Reference

    VENTX Gene Information

    HGNC symbol
    VENTX 
    Aliases
    NA88A; HPX42B; VENTX2 
    Common name
    VENT homeobox 
    Entrez Id
    27287
    Description
    This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]

    VENTX Ontologies

    Gene Ontology
    Process: GO:7275; multicellular organism development
    GO:6355; regulation of transcription, DNA-templated
    Cellular component: GO:5634; nucleus
    Function: GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    Show all GO terms

    Homologs of VENTX in Model Organisms

    Danio rerio
    vox

    External links

    OMIM
    607158
    Ensembl
    ENSG00000151650
    Entrez Gene
    27287
    UniGene
    125231
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    VENTX
    GeneCards
    VENTX