Cell Senescence Entries for VEGFA

Cell Types
Dermal endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Supplementation with VEGFA in dermal microvascular endothelial cells resulted in cells having a longer replicative lifespan, normal nuclear morphology being largely maintained even at later passages.
Primary Reference

    VEGFA Gene Information

    HGNC symbol
    VEGFA 
    Aliases
    VPF; VEGF; MVCD1 
    Common name
    vascular endothelial growth factor A 
    Entrez Id
    7422
    Description
    This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]

    VEGFA Ontologies

    Gene Ontology
    Process: GO:38190; VEGF-activated neuropilin signaling pathway
    GO:32147; activation of protein kinase activity
    GO:1525; angiogenesis
    GO:48844; artery morphogenesis
    GO:1569; branching involved in blood vessel morphogenesis
    GO:48754; branching morphogenesis of an epithelial tube
    GO:48593; camera-type eye morphogenesis
    GO:48739; cardiac muscle fiber development
    GO:60948; cardiac vascular smooth muscle cell development
    GO:48469; cell maturation
    GO:2042; cell migration involved in sprouting angiogenesis
    And 82 more GO terms
    Cellular component: GO:9986; cell surface
    GO:5737; cytoplasm
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:16020; membrane
    GO:31093; platelet alpha granule lumen
    GO:5578; proteinaceous extracellular matrix
    GO:30141; secretory granule
    Function: GO:42056; chemoattractant activity
    GO:5125; cytokine activity
    GO:50840; extracellular matrix binding
    GO:1968; fibronectin binding
    GO:8083; growth factor activity
    GO:8201; heparin binding
    GO:42802; identical protein binding
    GO:5161; platelet-derived growth factor receptor binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    GO:42803; protein homodimerization activity
    And 5 more GO terms
    Show all GO terms

    Homologs of VEGFA in Model Organisms

    Danio rerio
    vegfab
    Mus musculus
    Vegfa
    Rattus norvegicus
    Vegfa

    In other databases

    GenAge human genes
    • This gene is present as VEGFA
    LongevityMap
    • This gene is present as VEGFA

    External links

    OMIM
    192240
    Ensembl
    ENSG00000112715
    Entrez Gene
    7422
    UniGene
    73793
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    VEGFA
    GeneCards
    VEGFA