Cell Senescence Entries for USP1

Cell Types
Lung fibroblast, Foreskin fibroblast
Cell Lines
WI-38, BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Observations
Silencing of USP1 expression in WI-38 and BJ cells resulted in cell-cycle arrest with senescence features. Repression of USP1 induced FANCD2 chromatin aggregation and replication stress. Replication was then repressed through FANCD2-FI-ATR-CHK1-p53-CDKN1A signalling. Thus, USP1 acts as a key senescence regulator by controlling genomic integrity.
Primary Reference

    USP1 Gene Information

    HGNC symbol
    USP1 
    Aliases
    UBP 
    Common name
    ubiquitin specific peptidase 1 
    Entrez Id
    7398
    Description
    This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

    USP1 Ontologies

    Gene Ontology
    Process: GO:42769; DNA damage response, detection of DNA damage
    GO:36297; interstrand cross-link repair
    GO:35520; monoubiquitinated protein deubiquitination
    GO:16579; protein deubiquitination
    GO:6282; regulation of DNA repair
    GO:9411; response to UV
    GO:1501; skeletal system development
    GO:6511; ubiquitin-dependent protein catabolic process
    Cellular component: GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:4197; cysteine-type endopeptidase activity
    GO:8233; peptidase activity
    GO:5515; protein binding
    GO:4843; thiol-dependent ubiquitin-specific protease activity
    Show all GO terms

    Homologs of USP1 in Model Organisms

    Danio rerio
    usp1
    Drosophila melanogaster
    BcDNA.LD22910
    Mus musculus
    Usp1
    Rattus norvegicus
    Usp1

    External links

    OMIM
    603478
    Ensembl
    ENSG00000162607
    Entrez Gene
    7398
    UniGene
    35086
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    USP1
    GeneCards
    USP1