Cell Senescence Entries for UBTD1

Cell Types
Prostate cancer, Gastric cancer, Colorectal cancer, Gastric epithelial, Lung fibroblast, Breast cancer
Cell Lines
GES-1, MKN28, KATO-III, SNU-1, SNU-16, MKN45, NCI-N87, SGC-7901, AGS, MCF-7, LoVo, PC-3, MRC-5
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Promotes
Observations
Ubiquitin domain-containing 1 (UBTD1) gene, a downstream target of p53, induced cellular senescence and acted as a novel tumor suppressor by a mechanism dependant on p53. Expression of UBTD1 increased upon cellular senescence induced by serial passaging of cultures or exposure to DNA-damaging drugs. Overexpression of UBTD1 induced senescence in human fibroblasts and cancer cells, along with attenuation of the transformed phenotype in cancer cells. These showed increased SA-beta-galactosidase activity.
Primary Reference

    UBTD1 Gene Information

    HGNC symbol
    UBTD1 
    Aliases
     
    Common name
    ubiquitin domain containing 1 
    Entrez Id
    80019
    Description
    The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]

    UBTD1 Ontologies

    Gene Ontology
    Process:
    Cellular component:
    Function: GO:5515; protein binding
    GO:43130; ubiquitin binding
    Show all GO terms

    Homologs of UBTD1 in Model Organisms

    Danio rerio
    ubtd1a
    Drosophila melanogaster
    CG1172
    Mus musculus
    Ubtd1
    Rattus norvegicus
    Ubtd1
    Schizosaccharomyces pombe
    SPAPB2B4.07

    External links

    OMIM
    616388
    Ensembl
    ENSG00000165886
    Entrez Gene
    80019
    UniGene
    500724
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    UBTD1
    GeneCards
    UBTD1