Cell Senescence Entries for TYK2

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

TYK2 Gene Information

HGNC symbol
TYK2 
Aliases
JTK1 
Common name
tyrosine kinase 2 
Entrez Id
7297
Description
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020].

TYK2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:35556; intracellular signal transduction
GO:18108; peptidyl-tyrosine phosphorylation
GO:19221; cytokine-mediated signaling pathway
GO:32729; positive regulation of interferon-gamma production
GO:32819; positive regulation of natural killer cell proliferation
GO:42102; positive regulation of T cell proliferation
GO:46427; positive regulation of receptor signaling pathway via JAK-STAT
GO:51142; positive regulation of NK T cell proliferation
GO:60337; type I interferon signaling pathway
GO:6955; immune response
GO:32740; positive regulation of interleukin-17 production
GO:98586; cellular response to virus
GO:2000318; positive regulation of T-helper 17 type immune response
GO:38196; type III interferon signaling pathway
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5856; cytoskeleton
GO:5634; nucleus
GO:5829; cytosol
GO:70062; extracellular exosome
GO:5886; plasma membrane
GO:42022; interleukin-12 receptor complex
GO:72536; interleukin-23 receptor complex
Function: GO:4672; protein kinase activity
GO:166; nucleotide binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:5515; protein binding
GO:31702; type 1 angiotensin receptor binding
GO:5131; growth hormone receptor binding
Hide GO terms

Homologs of TYK2 in Model Organisms

Danio rerio
tyk2
Drosophila melanogaster
hop
Mus musculus
Tyk2
Rattus norvegicus
Tyk2

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as hop

External links

OMIM
176941
Ensembl
ENSG00000105397
Entrez Gene
7297
UniGene
75516
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TYK2
GeneCards
TYK2