Cell Senescence Entries for TYK2

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    TYK2 Gene Information

    HGNC symbol
    TYK2 
    Aliases
    JTK1; IMD35 
    Common name
    tyrosine kinase 2 
    Entrez Id
    7297
    Description
    This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

    TYK2 Ontologies

    Gene Ontology
    Process: GO:30154; cell differentiation
    GO:16477; cell migration
    GO:45087; innate immune response
    GO:35556; intracellular signal transduction
    GO:38083; peptidyl-tyrosine autophosphorylation
    GO:6468; protein phosphorylation
    GO:42127; regulation of cell proliferation
    GO:60338; regulation of type I interferon-mediated signaling pathway
    GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
    GO:60337; type I interferon signaling pathway
    Cellular component: GO:5737; cytoplasm
    GO:5856; cytoskeleton
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:31234; extrinsic component of cytoplasmic side of plasma membrane
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:5131; growth hormone receptor binding
    GO:4715; non-membrane spanning protein tyrosine kinase activity
    GO:5515; protein binding
    GO:4713; protein tyrosine kinase activity
    GO:31702; type 1 angiotensin receptor binding
    Show all GO terms

    Homologs of TYK2 in Model Organisms

    Danio rerio
    tyk2
    Drosophila melanogaster
    hop
    Mus musculus
    Tyk2
    Rattus norvegicus
    Tyk2

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as hop

    External links

    OMIM
    176941
    Ensembl
    ENSG00000105397
    Entrez Gene
    7297
    UniGene
    75516
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TYK2
    GeneCards
    TYK2