Cell Senescence Entries for TXNIP

Cell Types
Lung fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Overexpression, Knockout
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Promotes
Observations
VDUP1 (TXNIP) is up-regulated during the senescence process and its overexpression in young cells lead to typical signs of senescence. Contrastly, knockdown of VDUP1 delayed the onset of Ras-induced cellular senescence.
Primary Reference

    TXNIP Gene Information

    HGNC symbol
    TXNIP 
    Aliases
    THIF; VDUP1; ARRDC6; HHCPA78; EST01027 
    Common name
    thioredoxin interacting protein 
    Entrez Id
    10628
    Description
    This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

    TXNIP Ontologies

    Gene Ontology
    Process: GO:7049; cell cycle
    GO:71228; cellular response to tumor cell
    GO:30216; keratinocyte differentiation
    GO:43086; negative regulation of catalytic activity
    GO:51782; negative regulation of cell division
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:48008; platelet-derived growth factor receptor signaling pathway
    GO:43065; positive regulation of apoptotic process
    GO:6606; protein import into nucleus
    GO:42127; regulation of cell proliferation
    GO:51592; response to calcium ion
    And 8 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5758; mitochondrial intermembrane space
    GO:5634; nucleus
    Function: GO:4857; enzyme inhibitor activity
    GO:5515; protein binding
    GO:31625; ubiquitin protein ligase binding
    Show all GO terms

    Homologs of TXNIP in Model Organisms

    Caenorhabditis elegans
    arrd-6
    Danio rerio
    txnipb
    Drosophila melanogaster
    CG2641
    Mus musculus
    Txnip
    Rattus norvegicus
    Txnip

    In other databases

    GenAge microarray genes
    • This gene is present as TXNIP

    External links

    OMIM
    606599
    Ensembl
    ENSG00000265972
    Entrez Gene
    10628
    UniGene
    533977
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TXNIP
    GeneCards
    TXNIP