Cell Senescence Entries for TXN

Cell Types
Foreskin fibroblast
Cell Lines
BJ, BJE-LT
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Suppression of TRX1 (TXN) expression via RNA interference induced premature senescence in young human skin fibroblasts through upregulation of the p53/p21 and p16 tumor suppressor pathways.
Primary Reference

    TXN Gene Information

    HGNC symbol
    TXN 
    Aliases
    TRX; TRDX; TRX1 
    Common name
    thioredoxin 
    Entrez Id
    7295
    Description
    The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

    TXN Ontologies

    Gene Ontology
    Process: GO:32148; activation of protein kinase B activity
    GO:8283; cell proliferation
    GO:45454; cell redox homeostasis
    GO:7267; cell-cell signaling
    GO:98869; cellular oxidant detoxification
    GO:6662; glycerol ether metabolic process
    GO:6928; movement of cell or subcellular component
    GO:1903206; negative regulation of hydrogen peroxide-induced cell death
    GO:46826; negative regulation of protein export from nucleus
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:15949; nucleobase-containing small molecule interconversion
    And 11 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5739; mitochondrion
    GO:5634; nucleus
    Function: GO:3723; RNA binding
    GO:16671; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
    GO:15037; peptide disulfide oxidoreductase activity
    GO:5515; protein binding
    GO:15035; protein disulfide oxidoreductase activity
    GO:47134; protein-disulfide reductase activity
    GO:4791; thioredoxin-disulfide reductase activity
    Show all GO terms

    Homologs of TXN in Model Organisms

    Danio rerio
    zgc:56493
    Drosophila melanogaster
    TrxT
    Mus musculus
    Txn
    Rattus norvegicus
    Txn
    Saccharomyces cerevisiae
    TRX1
    Schizosaccharomyces pombe
    trx1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as TrxT
    • A homolog of this gene for Mus musculus is present as Txn1
    • A homolog of this gene for Saccharomyces cerevisiae is present as TRX1
    GenAge human genes
    • This gene is present as TXN

    External links

    OMIM
    187700
    Ensembl
    ENSG00000136810
    Entrez Gene
    7295
    UniGene
    435136
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TXN
    GeneCards
    TXN