Cell Senescence Entries for TRPM8

Cell Types
Pancreatic cancer
Cell Lines
BxPC-3, PANC-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
RNA interference of TRPM8 induced replicative senescence in pancreatic adenocarcinoma cells.
Primary Reference

    TRPM8 Gene Information

    HGNC symbol
    TRPM8 
    Aliases
    TRPP8; LTRPC6 
    Common name
    transient receptor potential cation channel subfamily M member 8 
    Entrez Id
    79054
    Description

    TRPM8 Ontologies

    Gene Ontology
    Process: GO:70588; calcium ion transmembrane transport
    GO:6874; cellular calcium ion homeostasis
    GO:16048; detection of temperature stimulus
    GO:51289; protein homotetramerization
    GO:70207; protein homotrimerization
    GO:9409; response to cold
    GO:50955; thermoception
    Cellular component: GO:5789; endoplasmic reticulum membrane
    GO:9897; external side of plasma membrane
    GO:16021; integral component of membrane
    GO:45121; membrane raft
    GO:5886; plasma membrane
    Function: GO:5262; calcium channel activity
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    Show all GO terms

    Homologs of TRPM8 in Model Organisms

    Mus musculus
    Trpm8
    Rattus norvegicus
    Trpm8

    External links

    OMIM
    606678
    Ensembl
    ENSG00000144481
    Entrez Gene
    79054
    UniGene
    366053
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TRPM8
    GeneCards
    TRPM8