Cell Senescence Entries for TPR

Cell Types
Cervical cancer, Melanoma, Osteosarcoma
Cell Lines
HeLa, U2OS, A375
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Depletion of TPR by RNA interference triggered G0-G1 arrest and ultimately induced a senescent-like phenotype dependent on the presence of p53 in HeLa cells as well as in U2OS osteosarcoma and A375 melanoma cells.
Primary Reference

    TPR Gene Information

    HGNC symbol
    TPR 
    Aliases
     
    Common name
    translocated promoter region, nuclear basket protein 
    Entrez Id
    7175
    Description
    This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

    TPR Ontologies

    Gene Ontology
    Process: GO:189; MAPK import into nucleus
    GO:6405; RNA export from nucleus
    GO:6404; RNA import into nucleus
    GO:8150; biological_process
    GO:51301; cell division
    GO:34605; cellular response to heat
    GO:35457; cellular response to interferon-alpha
    GO:31047; gene silencing by RNA
    GO:75733; intracellular transport of virus
    GO:6406; mRNA export from nucleus
    GO:31990; mRNA export from nucleus in response to heat stress
    And 29 more GO terms
    Cellular component: GO:5575; cellular_component
    GO:5737; cytoplasm
    GO:5868; cytoplasmic dynein complex
    GO:19898; extrinsic component of membrane
    GO:776; kinetochore
    GO:72686; mitotic spindle
    GO:5635; nuclear envelope
    GO:42405; nuclear inclusion body
    GO:31965; nuclear membrane
    GO:34399; nuclear periphery
    GO:5643; nuclear pore
    And 4 more GO terms
    Function: GO:3723; RNA binding
    GO:3682; chromatin binding
    GO:70840; dynein complex binding
    GO:31072; heat shock protein binding
    GO:3729; mRNA binding
    GO:51019; mitogen-activated protein kinase binding
    GO:3674; molecular_function
    GO:5487; nucleocytoplasmic transporter activity
    GO:43495; protein anchor
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    And 3 more GO terms
    Show all GO terms

    Homologs of TPR in Model Organisms

    Caenorhabditis elegans
    npp-21
    Danio rerio
    tprb
    Drosophila melanogaster
    Mtor
    Mus musculus
    Tpr
    Rattus norvegicus
    Tpr
    Saccharomyces cerevisiae
    MLP2
    Schizosaccharomyces pombe
    nup211

    External links

    OMIM
    189940
    Ensembl
    ENSG00000047410
    Entrez Gene
    7175
    UniGene
    279640
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TPR
    GeneCards
    TPR