Cell Senescence Entries for TP63

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Expression of the alpha, beta or gamma isoforms of TAp63 (TP63) in foreskin fibroblasts (BJ cells) induced cellular senescence, with cells displaying increased SA-beta-galactosidase activity and decreased BrdU incorporation.
Primary Reference

    TP63 Gene Information

    HGNC symbol
    TP63 
    Aliases
    AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B) 
    Common name
    tumor protein p63 
    Entrez Id
    8626
    Description
    This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]

    TP63 Ontologies

    Gene Ontology
    Process: GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    GO:7219; Notch signaling pathway
    GO:6915; apoptotic process
    GO:34644; cellular response to UV
    GO:6338; chromatin remodeling
    GO:60197; cloacal septation
    GO:7499; ectoderm and mesoderm interaction
    GO:30326; embryonic limb morphogenesis
    GO:10481; epidermal cell division
    GO:2064; epithelial cell development
    GO:1736; establishment of planar polarity
    And 47 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:30425; dendrite
    GO:5739; mitochondrion
    GO:790; nuclear chromatin
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5791; rough endoplasmic reticulum
    GO:5667; transcription factor complex
    Function: GO:3677; DNA binding
    GO:97371; MDM2/MDM4 family protein binding
    GO:50699; WW domain binding
    GO:3682; chromatin binding
    GO:3684; damaged DNA binding
    GO:3690; double-stranded DNA binding
    GO:42802; identical protein binding
    GO:46872; metal ion binding
    GO:2039; p53 binding
    GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    And 5 more GO terms
    Show all GO terms

    Homologs of TP63 in Model Organisms

    Danio rerio
    tp63
    Mus musculus
    Tp63
    Rattus norvegicus
    Tp63

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Trp63
    GenAge human genes
    • This gene is present as TP63

    External links

    OMIM
    603273
    Ensembl
    ENSG00000073282
    Entrez Gene
    8626
    UniGene
    137569
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TP63
    GeneCards
    TP63