Cell Senescence Entries for TOP1

Cell Types
Lung fibroblast
Cell Lines
WI-38, IMR-90
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Knockdown of topoisomerase I (TOP1) lead to an increased replicative potential, a decrease in senescence markers and a diminished DNA damage response. Conversely, the constitutive expression of TOP1 induced growth arrest and the appearance of a senescence phenotype.
Primary Reference

    TOP1 Gene Information

    HGNC symbol
    TOP1 
    Aliases
    TOPI 
    Common name
    topoisomerase (DNA) I 
    Entrez Id
    7150
    Description
    This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

    TOP1 Ontologies

    Gene Ontology
    Process: GO:6260; DNA replication
    GO:6265; DNA topological change
    GO:6338; chromatin remodeling
    GO:7059; chromosome segregation
    GO:32922; circadian regulation of gene expression
    GO:7623; circadian rhythm
    GO:40016; embryonic cleavage
    GO:18105; peptidyl-serine phosphorylation
    GO:16310; phosphorylation
    GO:12501; programmed cell death
    GO:16925; protein sumoylation
    And 3 more GO terms
    Cellular component: GO:9330; DNA topoisomerase complex (ATP-hydrolyzing)
    GO:932; P-body
    GO:1650; fibrillar center
    GO:228; nuclear chromosome
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43204; perikaryon
    GO:32993; protein-DNA complex
    GO:31298; replication fork protection complex
    Function: GO:5524; ATP binding
    GO:3677; DNA binding
    GO:3917; DNA topoisomerase type I activity
    GO:3723; RNA binding
    GO:3682; chromatin binding
    GO:1046; core promoter sequence-specific DNA binding
    GO:3690; double-stranded DNA binding
    GO:5515; protein binding
    GO:19904; protein domain specific binding
    GO:4674; protein serine/threonine kinase activity
    GO:3697; single-stranded DNA binding
    And 2 more GO terms
    Show all GO terms

    Homologs of TOP1 in Model Organisms

    Danio rerio
    top1l
    Drosophila melanogaster
    Top1
    Mus musculus
    Top1
    Rattus norvegicus
    Top1

    In other databases

    GenAge human genes
    • This gene is present as TOP1

    External links

    OMIM
    126420
    Ensembl
    ENSG00000198900
    Entrez Gene
    7150
    UniGene
    472737
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TOP1
    GeneCards
    TOP1