Cell Senescence Entries for TNFSF13

Cell Types
Colon cancer
Cell Lines
SW480
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of APRIL (TNFSF13) levels in colon carcinoma cells inhibited cell proliferation and partially led to a senescence phenotype, including characteristic morphology and increased SA-beta-galactosidase activity.
Primary Reference

    TNFSF13 Gene Information

    HGNC symbol
    TNFSF13 
    Aliases
    APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715 
    Common name
    TNF superfamily member 13 
    Entrez Id
    8741
    Description
    The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

    TNFSF13 Ontologies

    Gene Ontology
    Process: GO:6955; immune response
    GO:8284; positive regulation of cell proliferation
    GO:48298; positive regulation of isotype switching to IgA isotypes
    GO:43488; regulation of mRNA stability
    GO:7165; signal transduction
    GO:33209; tumor necrosis factor-mediated signaling pathway
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:16020; membrane
    GO:5654; nucleoplasm
    Function: GO:5125; cytokine activity
    GO:5102; receptor binding
    GO:5164; tumor necrosis factor receptor binding
    Show all GO terms

    Homologs of TNFSF13 in Model Organisms

    Danio rerio
    tnfsf13
    Mus musculus
    Tnfsf13
    Rattus norvegicus
    Tnfsf13

    External links

    OMIM
    604472
    Ensembl
    ENSG00000161955
    Entrez Gene
    8741
    UniGene
    54673
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TNFSF13
    GeneCards
    TNFSF13