Cell Senescence Entries for TLR3

Cell Types
Fibroblast, Keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
SORBS2 and TLR3 were found to induce senescence in primary human fibroblasts and keratinocytes but not in HPV-immortalized cell lines.
Primary Reference

    TLR3 Gene Information

    HGNC symbol
    TLR3 
    Aliases
    CD283; IIAE2 
    Common name
    toll like receptor 3 
    Entrez Id
    7098
    Description
    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

    TLR3 Ontologies

    Gene Ontology
    Process: GO:7249; I-kappaB kinase/NF-kappaB signaling
    GO:7252; I-kappaB phosphorylation
    GO:2756; MyD88-independent toll-like receptor signaling pathway
    GO:35666; TRIF-dependent toll-like receptor signaling pathway
    GO:7250; activation of NF-kappaB-inducing kinase activity
    GO:97190; apoptotic signaling pathway
    GO:35690; cellular response to drug
    GO:71360; cellular response to exogenous dsRNA
    GO:35458; cellular response to interferon-beta
    GO:71346; cellular response to interferon-gamma
    GO:71260; cellular response to mechanical stimulus
    And 38 more GO terms
    Cellular component: GO:139; Golgi membrane
    GO:9986; cell surface
    GO:5737; cytoplasm
    GO:5769; early endosome
    GO:36020; endolysosome membrane
    GO:5789; endoplasmic reticulum membrane
    GO:10008; endosome membrane
    GO:5887; integral component of plasma membrane
    GO:5622; intracellular
    GO:5765; lysosomal membrane
    GO:16020; membrane
    And 1 more GO terms
    Function: GO:3725; double-stranded RNA binding
    GO:42802; identical protein binding
    GO:5515; protein binding
    GO:4872; receptor activity
    GO:4888; transmembrane signaling receptor activity
    Show all GO terms

    Homologs of TLR3 in Model Organisms

    Danio rerio
    tlr3
    Mus musculus
    Tlr3
    Rattus norvegicus
    Tlr3

    External links

    OMIM
    603029
    Ensembl
    ENSG00000164342
    Entrez Gene
    7098
    UniGene
    657724
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TLR3
    GeneCards
    TLR3