Cell Senescence Entries for TGFB1I1

Cell Types
Fibroblast
Cell Lines
KMST-6, SUSM-1
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
The ectopic expression of HIC-5 (TGFB1I1) in nontumorigenic immortalized human fibroblasts decreased colony-forming efficiency and lead to a senescence-like phenotype, including growth retardation, senescence-like morphology and increased expression of Cip1/WAF1/sdi1. In contrast, antisense RNA expression of hic-5 in normal diploid fibroblasts delayed the senescence process.
Primary Reference

    TGFB1I1 Gene Information

    HGNC symbol
    TGFB1I1 
    Aliases
    HIC5; ARA55; HIC-5; TSC-5 
    Common name
    transforming growth factor beta 1 induced transcript 1 
    Entrez Id
    7041
    Description
    This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

    TGFB1I1 Ontologies

    Gene Ontology
    Process: GO:16055; Wnt signaling pathway
    GO:30521; androgen receptor signaling pathway
    GO:7155; cell adhesion
    GO:45165; cell fate commitment
    GO:30855; epithelial cell differentiation
    GO:16331; morphogenesis of embryonic epithelium
    GO:8285; negative regulation of cell proliferation
    GO:45599; negative regulation of fat cell differentiation
    GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
    GO:10718; positive regulation of epithelial to mesenchymal transition
    GO:45893; positive regulation of transcription, DNA-templated
    And 5 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5856; cytoskeleton
    GO:31012; extracellular matrix
    GO:5925; focal adhesion
    GO:5622; intracellular
    GO:16363; nuclear matrix
    Function: GO:70411; I-SMAD binding
    GO:48495; Roundabout binding
    GO:50681; androgen receptor binding
    GO:5515; protein binding
    GO:3713; transcription coactivator activity
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of TGFB1I1 in Model Organisms

    Caenorhabditis elegans
    pxl-1
    Mus musculus
    Tgfb1i1
    Rattus norvegicus
    Tgfb1i1

    External links

    OMIM
    602353
    Ensembl
    ENSG00000140682
    Entrez Gene
    7041
    UniGene
    513530
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TGFB1I1
    GeneCards
    TGFB1I1