Cell Senescence Entries for TFDP1

Cell Types
Lung cancer, Cervical cancer, Lung fibroblast
Cell Lines
HeLa, A549, WI-38
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Impairment of TFDP1, but not TFDP2, increased senescence in diploid fibroblasts but not in p53 null Saos-2 osteosarcoma cells.
Primary Reference

    TFDP1 Gene Information

    HGNC symbol
    TFDP1 
    Aliases
    DP1; DILC; Dp-1; DRTF1 
    Common name
    transcription factor Dp-1 
    Entrez Id
    7027
    Description
    This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

    TFDP1 Ontologies

    Gene Ontology
    Process: GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    GO:8283; cell proliferation
    GO:70345; negative regulation of fat cell proliferation
    GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:6357; regulation of transcription from RNA polymerase II promoter
    GO:6351; transcription, DNA-templated
    Cellular component: GO:5829; cytosol
    GO:5739; mitochondrion
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5667; transcription factor complex
    Function: GO:3677; DNA binding
    GO:981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
    GO:5515; protein binding
    GO:19904; protein domain specific binding
    GO:3713; transcription coactivator activity
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:8134; transcription factor binding
    Show all GO terms

    Homologs of TFDP1 in Model Organisms

    Danio rerio
    tfdp1a
    Mus musculus
    Tfdp1

    In other databases

    GenAge human genes
    • This gene is present as TFDP1

    External links

    OMIM
    189902
    Ensembl
    ENSG00000198176
    Entrez Gene
    7027
    UniGene
    79353
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TFDP1
    GeneCards
    TFDP1