Cell Senescence Entries for TERF2
- Cell Types
- Neuroblastoma
- Cell Lines
- SH-SY5Y
- Cancer Cell?
- Yes
- Method
- Knockout
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- Knockdown of TERF2 in neuroblastoma cells resulted in a significant reduction in their proliferation, accompanied by a decrease of BrdU incorporation, limited growth rate and increased expression of SA-beta-galactosidase.
- Primary Reference
TERF2 Gene Information
- HGNC symbol
- TERF2
- Aliases
- TRF2; TRBF2
- Common name
- telomeric repeat binding factor 2
- Entrez Id
- 7014
- Description
- This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]
TERF2 Ontologies
- Gene Ontology
-
Process: GO:6278; RNA-dependent DNA biosynthetic process
GO:7049; cell cycle
GO:90398; cellular senescence
GO:1903770; negative regulation of beta-galactosidase activity
GO:2000773; negative regulation of cellular senescence
GO:1905778; negative regulation of exonuclease activity
GO:10629; negative regulation of gene expression
GO:1904430; negative regulation of t-circle formation
GO:1904354; negative regulation of telomere capping
GO:32205; negative regulation of telomere maintenance
GO:32208; negative regulation of telomere maintenance via recombination
And 16 more GO terms Cellular component: GO:30870; Mre11 complex
GO:781; chromosome, telomeric region
GO:16604; nuclear body
GO:784; nuclear chromosome, telomeric region
GO:783; nuclear telomere cap complex
GO:5654; nucleoplasm
GO:5634; nucleus
GO:70187; shelterin complex
Function: GO:98505; G-rich strand telomeric DNA binding
GO:3691; double-stranded telomeric DNA binding
GO:19899; enzyme binding
GO:44877; macromolecular complex binding
GO:8022; protein C-terminus binding
GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:3720; telomerase activity
GO:42162; telomeric DNA binding
Homologs of TERF2 in Model Organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Terf2
- GenAge human genes
- This gene is present as TERF2
- LongevityMap
- This gene is present as TERF2
External links
- OMIM
- 602027
- Ensembl
- ENSG00000132604
- Entrez Gene
- 7014
- UniGene
- 63335
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TERF2
- GeneCards
- TERF2