Cell Senescence Entries for TERF2

Cell Types
Neuroblastoma
Cell Lines
SH-SY5Y
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of TERF2 in neuroblastoma cells resulted in a significant reduction in their proliferation, accompanied by a decrease of BrdU incorporation, limited growth rate and increased expression of SA-beta-galactosidase.
Primary Reference

    TERF2 Gene Information

    HGNC symbol
    TERF2 
    Aliases
    TRF2; TRBF2 
    Common name
    telomeric repeat binding factor 2 
    Entrez Id
    7014
    Description
    This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]

    TERF2 Ontologies

    Gene Ontology
    Process: GO:6278; RNA-dependent DNA biosynthetic process
    GO:7049; cell cycle
    GO:90398; cellular senescence
    GO:1903770; negative regulation of beta-galactosidase activity
    GO:2000773; negative regulation of cellular senescence
    GO:1905778; negative regulation of exonuclease activity
    GO:10629; negative regulation of gene expression
    GO:1904430; negative regulation of t-circle formation
    GO:1904354; negative regulation of telomere capping
    GO:32205; negative regulation of telomere maintenance
    GO:32208; negative regulation of telomere maintenance via recombination
    And 16 more GO terms
    Cellular component: GO:30870; Mre11 complex
    GO:781; chromosome, telomeric region
    GO:16604; nuclear body
    GO:784; nuclear chromosome, telomeric region
    GO:783; nuclear telomere cap complex
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:70187; shelterin complex
    Function: GO:98505; G-rich strand telomeric DNA binding
    GO:3691; double-stranded telomeric DNA binding
    GO:19899; enzyme binding
    GO:44877; macromolecular complex binding
    GO:8022; protein C-terminus binding
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    GO:3720; telomerase activity
    GO:42162; telomeric DNA binding
    Show all GO terms

    Homologs of TERF2 in Model Organisms

    Danio rerio
    terfa
    Mus musculus
    Terf2
    Rattus norvegicus
    Terf2

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Terf2
    GenAge human genes
    • This gene is present as TERF2
    LongevityMap
    • This gene is present as TERF2

    External links

    OMIM
    602027
    Ensembl
    ENSG00000132604
    Entrez Gene
    7014
    UniGene
    63335
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TERF2
    GeneCards
    TERF2