Cell Senescence Entries for TERC

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
TERC is the RNA component of telomerase. Cervical cancer cells (HeLa) transfected with antisense hTR (TERC) lost telomeric DNA and their proliferative capacity after 23 to 26 doublings.
Primary Reference

    TERC Gene Information

    HGNC symbol
    TERC 
    Aliases
    TR; hTR; TRC3; DKCA1; PFBMFT2; SCARNA19 
    Common name
    telomerase RNA component 
    Entrez Id
    7012
    Description
    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia. [provided by RefSeq, Jul 2008]

    TERC Ontologies

    Gene Ontology
    Process:
    Cellular component:
    Function:
    Show all GO terms

    Homologs of TERC in Model Organisms

    No homologs found

    In other databases

    GenAge human genes
    • This gene is present as TERC
    LongevityMap
    • This gene is present as TERC

    External links

    OMIM
    602322
    Ensembl
    ENSG00000270141
    Entrez Gene
    7012
    UniGene
    436182
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TERC
    GeneCards
    TERC