Cell Senescence Entries for TBX2

Cell Types
Melanoma
Cell Lines
B16
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Expression of dnTBX2, a dominant-negative of endogenous TBX2, induced senescence in CDKN2A-null B16 melanoma cells, with an observed increase in the level of p21, increased formation of SA-heterochromatin foci, increased SA-beta-galactosidase activity and reduced proliferation.
Primary Reference

    TBX2 Gene Information

    HGNC symbol
    TBX2 
    Aliases
     
    Common name
    T-box 2 
    Entrez Id
    6909
    Description
    This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]

    TBX2 Ontologies

    Gene Ontology
    Process: GO:7219; Notch signaling pathway
    GO:35909; aorta morphogenesis
    GO:36302; atrioventricular canal development
    GO:48738; cardiac muscle tissue development
    GO:7569; cell aging
    GO:90398; cellular senescence
    GO:60560; developmental growth involved in morphogenesis
    GO:48596; embryonic camera-type eye morphogenesis
    GO:42733; embryonic digit morphogenesis
    GO:35050; embryonic heart tube development
    GO:3203; endocardial cushion morphogenesis
    And 17 more GO terms
    Cellular component: GO:5634; nucleus
    GO:5667; transcription factor complex
    Function: GO:3677; DNA binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    GO:1078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of TBX2 in Model Organisms

    Danio rerio
    tbx2a
    Mus musculus
    Tbx2

    External links

    OMIM
    600747
    Ensembl
    ENSG00000121068
    Entrez Gene
    6909
    UniGene
    531085
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TBX2
    GeneCards
    TBX2