Cell Senescence Entries for TACC3

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
RNAi-mediated depletion of TACC3 in breast carcinoma cells resulted in a progressive loss of the pro-apoptotic Bcl-2 protein Bim, upregulation of p21, downregulation of the RB and extracellular signal-regulated kinase 1/2, ultimately leading to cell arrest in the G1 phase. Cells showed a senescent phenotype including formation of SA-heterochromatin foci and increased SA-beta-galactosidase activity.
Primary Reference

    TACC3 Gene Information

    HGNC symbol
    TACC3 
    Aliases
    ERIC1; ERIC-1 
    Common name
    transforming acidic coiled-coil containing protein 3 
    Entrez Id
    10460
    Description
    This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]

    TACC3 Ontologies

    Gene Ontology
    Process: GO:51301; cell division
    GO:8283; cell proliferation
    GO:21987; cerebral cortex development
    GO:7091; metaphase/anaphase transition of mitotic cell cycle
    GO:1902850; microtubule cytoskeleton organization involved in mitosis
    GO:60236; regulation of mitotic spindle organization
    Cellular component: GO:5737; cytoplasm
    GO:15630; microtubule cytoskeleton
    GO:5815; microtubule organizing center
    GO:922; spindle pole
    Function: GO:5515; protein binding
    Show all GO terms

    Homologs of TACC3 in Model Organisms

    Danio rerio
    tacc3
    Mus musculus
    Tacc3

    External links

    OMIM
    605303
    Ensembl
    ENSG00000013810
    Entrez Gene
    10460
    UniGene
    104019
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    TACC3
    GeneCards
    TACC3