Cell Senescence Entries for SYK

Cell Types
Melanoma
Cell Lines
A375, SK-MEL-28, 501-mel
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Expression of SYK in melanoma cells, which normally display lost expression, induced p53-dependent expression of p21 and promoted a senescence-like phenotype, including enlarged cell morphology, increased SA-beta-galactosidase activity and an increase in SA-heterochromatin foci.
Primary Reference

    SYK Gene Information

    HGNC symbol
    SYK 
    Aliases
    p72-Syk 
    Common name
    spleen associated tyrosine kinase 
    Entrez Id
    6850
    Description
    This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

    SYK Ontologies

    Gene Ontology
    Process: GO:50853; B cell receptor signaling pathway
    GO:38095; Fc-epsilon receptor signaling pathway
    GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
    GO:7257; activation of JUN kinase activity
    GO:2250; adaptive immune response
    GO:1525; angiogenesis
    GO:9887; animal organ morphogenesis
    GO:43366; beta selection
    GO:48514; blood vessel morphogenesis
    GO:8283; cell proliferation
    GO:71404; cellular response to low-density lipoprotein particle stimulus
    And 47 more GO terms
    Cellular component: GO:19815; B cell receptor complex
    GO:42101; T cell receptor complex
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:32009; early phagosome
    GO:31234; extrinsic component of cytoplasmic side of plasma membrane
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:43234; protein complex
    Function: GO:5524; ATP binding
    GO:42169; SH2 domain binding
    GO:35325; Toll-like receptor binding
    GO:5178; integrin binding
    GO:4715; non-membrane spanning protein tyrosine kinase activity
    GO:19902; phosphatase binding
    GO:1784; phosphotyrosine binding
    GO:5515; protein binding
    GO:4672; protein kinase activity
    GO:19901; protein kinase binding
    GO:4674; protein serine/threonine kinase activity
    And 3 more GO terms
    Show all GO terms

    Homologs of SYK in Model Organisms

    Danio rerio
    syk
    Drosophila melanogaster
    shark
    Mus musculus
    Syk
    Rattus norvegicus
    Syk

    In other databases

    LongevityMap
    • This gene is present as SYK

    External links

    OMIM
    600085
    Ensembl
    ENSG00000165025
    Entrez Gene
    6850
    UniGene
    371720
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SYK
    GeneCards
    SYK