Cell Senescence Entries for SUPT5H

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Observations
Knockdown of Spt5 (SUPT5H) caused senescence, with cells arrested in the G1 phase and apoptosis.
Primary Reference

    SUPT5H Gene Information

    HGNC symbol
    SUPT5H 
    Aliases
    SPT5; SPT5H; Tat-CT1 
    Common name
    SPT5 homolog, DSIF elongation factor subunit 
    Entrez Id
    6829
    Description

    SUPT5H Ontologies

    Gene Ontology
    Process: GO:6370; 7-methylguanosine mRNA capping
    GO:6354; DNA-templated transcription, elongation
    GO:7049; cell cycle
    GO:6338; chromatin remodeling
    GO:32785; negative regulation of DNA-templated transcription, elongation
    GO:1900364; negative regulation of mRNA polyadenylation
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:32786; positive regulation of DNA-templated transcription, elongation
    GO:16239; positive regulation of macroautophagy
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:50434; positive regulation of viral transcription
    And 5 more GO terms
    Cellular component: GO:32044; DSIF complex
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3723; RNA binding
    GO:3682; chromatin binding
    GO:19899; enzyme binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    Show all GO terms

    Homologs of SUPT5H in Model Organisms

    Caenorhabditis elegans
    spt-5
    Danio rerio
    supt5h
    Drosophila melanogaster
    Spt5
    Mus musculus
    Supt5h
    Rattus norvegicus
    Supt5h
    Saccharomyces cerevisiae
    SPT5
    Schizosaccharomyces pombe
    spt5

    External links

    OMIM
    602102
    Ensembl
    ENSG00000196235
    Entrez Gene
    6829
    UniGene
    631604
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SUPT5H
    GeneCards
    SUPT5H