Cell Senescence Entries for STAT5B

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
STAT5B was overexpressed in normal lung fibroblasts. Constitutive activation of the JAK/STAT5 signalling pathway induced cellular senescence through the activation of the p53 and Rb tumor suppressor pathways and mitochondrial dysfunction.
Primary Reference

    STAT5B Gene Information

    HGNC symbol
    STAT5B 
    Aliases
    STAT5 
    Common name
    signal transducer and activator of transcription 5B 
    Entrez Id
    6777
    Description
    The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

    STAT5B Ontologies

    Gene Ontology
    Process: GO:6103; 2-oxoglutarate metabolic process
    GO:7259; JAK-STAT cascade
    GO:60397; JAK-STAT cascade involved in growth hormone signaling pathway
    GO:48541; Peyer's patch development
    GO:33077; T cell differentiation in thymus
    GO:43029; T cell homeostasis
    GO:255; allantoin metabolic process
    GO:71364; cellular response to epidermal growth factor stimulus
    GO:71363; cellular response to growth factor stimulus
    GO:32870; cellular response to hormone stimulus
    GO:6101; citrate metabolic process
    And 43 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:979; RNA polymerase II core promoter sequence-specific DNA binding
    GO:3682; chromatin binding
    GO:35259; glucocorticoid receptor binding
    GO:5515; protein binding
    GO:46983; protein dimerization activity
    GO:19903; protein phosphatase binding
    GO:4713; protein tyrosine kinase activity
    GO:4871; signal transducer activity
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of STAT5B in Model Organisms

    Mus musculus
    Stat5b
    Rattus norvegicus
    Stat5b

    In other databases

    GenAge human genes
    • This gene is present as STAT5B

    External links

    OMIM
    604260
    Ensembl
    ENSG00000173757
    Entrez Gene
    6777
    UniGene
    595276
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    STAT5B
    GeneCards
    STAT5B