Cell Senescence Entries for SREBF1

Cell Types
Fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Ectopic expression of the mature form of SREBP-1 (SREBF1) in primary young human diploid fibroblasts induced cellular senescence.
Primary Reference

    SREBF1 Gene Information

    HGNC symbol
    SREBF1 
    Aliases
    SREBP1; bHLHd1; SREBP1a; SREBP-1c 
    Common name
    sterol regulatory element binding transcription factor 1 
    Entrez Id
    6720
    Description
    This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016]

    SREBF1 Ontologies

    Gene Ontology
    Process: GO:7568; aging
    GO:71398; cellular response to fatty acid
    GO:9267; cellular response to starvation
    GO:8203; cholesterol metabolic process
    GO:7623; circadian rhythm
    GO:45444; fat cell differentiation
    GO:8286; insulin receptor signaling pathway
    GO:30522; intracellular receptor signaling pathway
    GO:8610; lipid biosynthetic process
    GO:6629; lipid metabolic process
    GO:30324; lung development
    And 21 more GO terms
    Cellular component: GO:12507; ER to Golgi transport vesicle membrane
    GO:139; Golgi membrane
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5789; endoplasmic reticulum membrane
    GO:16021; integral component of membrane
    GO:5635; nuclear envelope
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    Function: GO:3677; DNA binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
    GO:4879; RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
    GO:3682; chromatin binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:46983; protein dimerization activity
    GO:19901; protein kinase binding
    GO:32810; sterol response element binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    And 2 more GO terms
    Show all GO terms

    Homologs of SREBF1 in Model Organisms

    Danio rerio
    srebf1
    Mus musculus
    Srebf1
    Rattus norvegicus
    Srebf1

    In other databases

    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Srebf1
    LongevityMap
    • This gene is present as SREBF1

    External links

    OMIM
    184756
    Ensembl
    ENSG00000072310
    Entrez Gene
    6720
    UniGene
    592123
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SREBF1
    GeneCards
    SREBF1