Cell Senescence Entries for SPOP

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Mutation, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Zhu et al. (2016) SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. Cell Rep 13(6)1183-1193 (PubMed)

SPOP Gene Information

HGNC symbol
SPOP 
Aliases
BTBD32; TEF2 
Common name
speckle type BTB/POZ protein 
Entrez Id
8405
Description
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].

SPOP Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:30162; regulation of proteolysis
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:31463; Cul3-RING ubiquitin ligase complex
Function: GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
Show all GO terms

Homologs of SPOP in Model Organisms

Caenorhabditis elegans
bath-43
Caenorhabditis elegans
mel-26
Caenorhabditis elegans
bath-44
Danio rerio
spop
Drosophila melanogaster
rdx
Mus musculus
Spop
Rattus norvegicus
Spop

External links

OMIM
602650
Ensembl
ENSG00000121067
Entrez Gene
8405
UniGene
740407
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SPOP
GeneCards
SPOP