Cell Senescence Entries for SPIN1

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of SPINDLIN1 (SPIN1) in HeLa cells resulted in multinucleation with cells exhibiting characteristic features of senescence and apoptosis, including morphological alterations and increased SA-beta-galactosidase activity.
Primary Reference

    SPIN1 Gene Information

    HGNC symbol
    SPIN1 
    Aliases
    SPIN; TDRD24 
    Common name
    spindlin 1 
    Entrez Id
    10927
    Description

    SPIN1 Ontologies

    Gene Ontology
    Process: GO:16055; Wnt signaling pathway
    GO:16569; covalent chromatin modification
    GO:7276; gamete generation
    GO:51321; meiotic cell cycle
    GO:7275; multicellular organism development
    GO:30177; positive regulation of Wnt signaling pathway
    GO:9303; rRNA transcription
    Cellular component: GO:5829; cytosol
    GO:31965; nuclear membrane
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5819; spindle
    Function: GO:35064; methylated histone binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of SPIN1 in Model Organisms

    Danio rerio
    LOC792822
    Mus musculus
    Spin1
    Rattus norvegicus
    Spin1

    External links

    OMIM
    609936
    Ensembl
    ENSG00000106723
    Entrez Gene
    10927
    UniGene
    146804
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SPIN1
    GeneCards
    SPIN1