Cell Senescence Entries for SOX5

Cell Types
Glioma
Cell Lines
U-178MG, U-251MG, U-343MG, U-343MGa, U-1242MG
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Overexpression of SOX5, which is downregulated in glioma cells, inhibited clone formation and proliferation.
Primary Reference

    SOX5 Gene Information

    HGNC symbol
    SOX5 
    Aliases
    L-SOX5; LAMSHF; L-SOX5B; L-SOX5F 
    Common name
    SRY-box 5 
    Entrez Id
    6660
    Description
    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

    SOX5 Ontologies

    Gene Ontology
    Process: GO:55059; asymmetric neuroblast division
    GO:71560; cellular response to transforming growth factor beta stimulus
    GO:61036; positive regulation of cartilage development
    GO:32332; positive regulation of chondrocyte differentiation
    GO:2000741; positive regulation of mesenchymal stem cell differentiation
    GO:6355; regulation of transcription, DNA-templated
    GO:6366; transcription from RNA polymerase II promoter
    Cellular component: GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:5515; protein binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    Show all GO terms

    Homologs of SOX5 in Model Organisms

    Danio rerio
    sox5
    Mus musculus
    Sox5

    In other databases

    LongevityMap
    • This gene is present as SOX5

    External links

    OMIM
    604975
    Ensembl
    ENSG00000134532
    Entrez Gene
    6660
    UniGene
    434948
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SOX5
    GeneCards
    SOX5