Cell Senescence Entries for SOX2

Cell Types
Colon cancer, Embryonic kidney
Cell Lines
HEK293T, HCT116, WiDr
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
It was found that SOX2 induced autophagy enhanced cellular senescence by up-regulating tumor suppressors or senescence factors, including p16, p21 and phosphorylated p53 (Ser15).
Primary Reference

    SOX2 Gene Information

    HGNC symbol
    SOX2 
    Aliases
    ANOP3; MCOPS3 
    Common name
    SRY-box 2 
    Entrez Id
    6657
    Description
    This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

    SOX2 Ontologies

    Gene Ontology
    Process: GO:21984; adenohypophysis development
    GO:7050; cell cycle arrest
    GO:6325; chromatin organization
    GO:1714; endodermal cell fate specification
    GO:1654; eye development
    GO:30900; forebrain development
    GO:21781; glial cell fate commitment
    GO:48839; inner ear development
    GO:90090; negative regulation of canonical Wnt signaling pathway
    GO:50680; negative regulation of epithelial cell proliferation
    GO:45665; negative regulation of neuron differentiation
    And 18 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5667; transcription factor complex
    Function: GO:3677; DNA binding
    GO:35198; miRNA binding
    GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:44212; transcription regulatory region DNA binding
    GO:976; transcription regulatory region sequence-specific DNA binding
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of SOX2 in Model Organisms

    Danio rerio
    sox2
    Drosophila melanogaster
    SoxN
    Mus musculus
    Sox2
    Rattus norvegicus
    Sox2

    External links

    OMIM
    184429
    Ensembl
    ENSG00000181449
    Entrez Gene
    6657
    UniGene
    518438
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SOX2
    GeneCards
    SOX2