Cell Senescence Entries for SORBS2
- Cell Types
- Fibroblast, Keratinocyte
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Promotes
- Observations
- SORBS2 and TLR3 were found to induce senescence in primary human fibroblasts and keratinocytes but not in HPV-immortalized cell lines.
- Primary Reference
SORBS2 Gene Information
- HGNC symbol
- SORBS2
- Aliases
- ARGBP2; PRO0618
- Common name
- sorbin and SH3 domain containing 2
- Entrez Id
- 8470
- Description
- Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
SORBS2 Ontologies
- Gene Ontology
-
Process: GO:7015; actin filament organization
GO:8150; biological_process
GO:7155; cell adhesion
GO:61049; cell growth involved in cardiac muscle cell development
GO:16477; cell migration
Cellular component: GO:30018; Z disc
GO:15629; actin cytoskeleton
GO:16324; apical plasma membrane
GO:5925; focal adhesion
GO:30027; lamellipodium
GO:5634; nucleus
GO:48471; perinuclear region of cytoplasm
Function: GO:3723; RNA binding
GO:8093; cytoskeletal adaptor activity
GO:5515; protein binding
GO:5200; structural constituent of cytoskeleton
GO:8307; structural constituent of muscle
Homologs of SORBS2 in Model Organisms
External links
- OMIM
- 616349
- Ensembl
- ENSG00000154556
- Entrez Gene
- 8470
- UniGene
- 481342
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SORBS2
- GeneCards
- SORBS2