Cell Senescence Entries for SORBS2

Cell Types
Fibroblast, Keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
SORBS2 and TLR3 were found to induce senescence in primary human fibroblasts and keratinocytes but not in HPV-immortalized cell lines.
Primary Reference

    SORBS2 Gene Information

    HGNC symbol
    SORBS2 
    Aliases
    ARGBP2; PRO0618 
    Common name
    sorbin and SH3 domain containing 2 
    Entrez Id
    8470
    Description
    Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

    SORBS2 Ontologies

    Gene Ontology
    Process: GO:7015; actin filament organization
    GO:8150; biological_process
    GO:7155; cell adhesion
    GO:61049; cell growth involved in cardiac muscle cell development
    GO:16477; cell migration
    Cellular component: GO:30018; Z disc
    GO:15629; actin cytoskeleton
    GO:16324; apical plasma membrane
    GO:5925; focal adhesion
    GO:30027; lamellipodium
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    Function: GO:3723; RNA binding
    GO:8093; cytoskeletal adaptor activity
    GO:5515; protein binding
    GO:5200; structural constituent of cytoskeleton
    GO:8307; structural constituent of muscle
    Show all GO terms

    Homologs of SORBS2 in Model Organisms

    Danio rerio
    sorbs2b
    Mus musculus
    Sorbs2
    Rattus norvegicus
    Sorbs2

    External links

    OMIM
    616349
    Ensembl
    ENSG00000154556
    Entrez Gene
    8470
    UniGene
    481342
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SORBS2
    GeneCards
    SORBS2