Cell Senescence Entries for SOD1

Cell Types
Lung fibroblast
Cell Lines
WI-38, WI38-SV40
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
RNA interference of SOD1 induced cellular senescence in normal human fibroblasts, with cells exhibiting a flat and enlarged cell morphology, and an increase in SA-beta-galactosidase activity.
Primary Reference

    SOD1 Gene Information

    HGNC symbol
    SOD1 
    Aliases
    ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer 
    Common name
    superoxide dismutase 1 
    Entrez Id
    6647
    Description
    The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

    SOD1 Ontologies

    Gene Ontology
    Process: GO:187; activation of MAPK activity
    GO:8089; anterograde axonal transport
    GO:60088; auditory receptor cell stereocilium organization
    GO:7569; cell aging
    GO:6879; cellular iron ion homeostasis
    GO:71318; cellular response to ATP
    GO:71276; cellular response to cadmium ion
    GO:35865; cellular response to potassium ion
    GO:7566; embryo implantation
    GO:6749; glutathione metabolic process
    GO:60047; heart contraction
    And 50 more GO terms
    Cellular component: GO:1904115; axon cytoplasm
    GO:5737; cytoplasm
    GO:31410; cytoplasmic vesicle
    GO:5829; cytosol
    GO:32839; dendrite cytoplasm
    GO:31045; dense core granule
    GO:70062; extracellular exosome
    GO:31012; extracellular matrix
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:5764; lysosome
    And 11 more GO terms
    Function: GO:48365; Rac GTPase binding
    GO:51087; chaperone binding
    GO:5507; copper ion binding
    GO:42802; identical protein binding
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    GO:30346; protein phosphatase 2B binding
    GO:4784; superoxide dismutase activity
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of SOD1 in Model Organisms

    Caenorhabditis elegans
    sod-5
    Danio rerio
    sod1
    Drosophila melanogaster
    Sod
    Mus musculus
    Sod1
    Rattus norvegicus
    Sod1
    Saccharomyces cerevisiae
    SOD1
    Schizosaccharomyces pombe
    sod1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
    • A homolog of this gene for Drosophila melanogaster is present as Sod
    GenAge human genes
    • This gene is present as SOD1
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
    LongevityMap
    • This gene is present as SOD1

    External links

    OMIM
    147450
    Ensembl
    ENSG00000142168
    Entrez Gene
    6647
    UniGene
    443914
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SOD1
    GeneCards
    SOD1