Cell Senescence Entries for SOCS1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative, Oncogene-induced
Senescence Effect
Promotes
Observations
Expression of SOCS1 inhibited cell growth and induced senescence in normal lung fibroblasts, displaying an increase in SA-beta-galactosidase staining, accumulation of PML bodies, increased levels of p53 and p21, and a reduction in Rb1 phosphorylation. Inactivation of SOCS1 disabled p53-dependent senescence in response to oncogenic STAT5A and radiation-induced apoptosis in T cells.
Primary Reference

    SOCS1 Gene Information

    HGNC symbol
    SOCS1 
    Aliases
    JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1 
    Common name
    suppressor of cytokine signaling 1 
    Entrez Id
    8651
    Description
    This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

    SOCS1 Ontologies

    Gene Ontology
    Process: GO:7259; JAK-STAT cascade
    GO:71230; cellular response to amino acid stimulus
    GO:19221; cytokine-mediated signaling pathway
    GO:45444; fat cell differentiation
    GO:46426; negative regulation of JAK-STAT cascade
    GO:46627; negative regulation of insulin receptor signaling pathway
    GO:6469; negative regulation of protein kinase activity
    GO:45591; positive regulation of regulatory T cell differentiation
    GO:16567; protein ubiquitination
    GO:50707; regulation of cytokine secretion
    GO:40008; regulation of growth
    And 3 more GO terms
    Cellular component: GO:932; P-body
    GO:5737; cytoplasm
    GO:31410; cytoplasmic vesicle
    GO:5829; cytosol
    GO:5654; nucleoplasm
    Function: GO:5159; insulin-like growth factor receptor binding
    GO:19210; kinase inhibitor activity
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:4860; protein kinase inhibitor activity
    Show all GO terms

    Homologs of SOCS1 in Model Organisms

    Caenorhabditis elegans
    CELE_F39B2.5
    Danio rerio
    socs1a
    Drosophila melanogaster
    Socs44A
    Mus musculus
    Socs1
    Rattus norvegicus
    Socs1

    In other databases

    LongevityMap
    • This gene is present as SOCS1

    External links

    OMIM
    603597
    Ensembl
    ENSG00000185338
    Entrez Gene
    8651
    UniGene
    50640
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SOCS1
    GeneCards
    SOCS1