Cell Senescence Entries for SNAI1

Cell Types
Prostate cancer
Cell Lines
LNCaP, PC-3
Cancer Cell?
yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Suppression of Snail (SNAI1) expression induced senescence in LNCaP cells.
Primary Reference

    SNAI1 Gene Information

    HGNC symbol
    SNAI1 
    Aliases
    SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1 
    Common name
    snail family transcriptional repressor 1 
    Entrez Id
    6615
    Description
    The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

    SNAI1 Ontologies

    Gene Ontology
    Process: GO:61314; Notch signaling involved in heart development
    GO:60536; cartilage morphogenesis
    GO:16477; cell migration
    GO:1837; epithelial to mesenchymal transition
    GO:3198; epithelial to mesenchymal transition involved in endocardial cushion formation
    GO:31069; hair follicle morphogenesis
    GO:60972; left/right pattern formation
    GO:1707; mesoderm formation
    GO:43518; negative regulation of DNA damage response, signal transduction by p53 class mediator
    GO:60806; negative regulation of cell differentiation involved in embryonic placenta development
    GO:1902230; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
    And 10 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5634; nucleus
    Function: GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
    GO:19900; kinase binding
    GO:46872; metal ion binding
    GO:5515; protein binding
    GO:1078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of SNAI1 in Model Organisms

    Mus musculus
    Snai1
    Rattus norvegicus
    Snai1

    External links

    OMIM
    604238
    Ensembl
    ENSG00000124216
    Entrez Gene
    6615
    UniGene
    48029
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SNAI1
    GeneCards
    SNAI1