Cell Senescence Entries for SMG1

Cell Types
Retinal pigment epithelial, Embryonic kidney
Cell Lines
hTERT-RPE1, HEK293T
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Using a high-content siRNA screening assay for cell morphology and proliferation measures, 12 senescence-regulating kinases (including SMG1) and their senescence marker signatures were determined, including elevation of SA-beta-galactosidase, DNA damage and p53 or p16 expression.
Primary Reference

    SMG1 Gene Information

    HGNC symbol
    SMG1 
    Aliases
    ATX; LIP; 61E3.4 
    Common name
    SMG1, nonsense mediated mRNA decay associated PI3K related kinase 
    Entrez Id
    23049
    Description
    This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]

    SMG1 Ontologies

    Gene Ontology
    Process: GO:6281; DNA repair
    GO:6406; mRNA export from nucleus
    GO:184; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
    GO:18105; peptidyl-serine phosphorylation
    GO:46854; phosphatidylinositol phosphorylation
    GO:46777; protein autophosphorylation
    GO:32204; regulation of telomere maintenance
    GO:6950; response to stress
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:3723; RNA binding
    GO:46872; metal ion binding
    GO:5515; protein binding
    GO:4672; protein kinase activity
    GO:4674; protein serine/threonine kinase activity
    GO:42162; telomeric DNA binding
    Show all GO terms

    Homologs of SMG1 in Model Organisms

    Caenorhabditis elegans
    smg-1
    Danio rerio
    smg1
    Drosophila melanogaster
    Smg1
    Mus musculus
    Smg1
    Rattus norvegicus
    Smg1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as smg-1

    External links

    OMIM
    607032
    Ensembl
    ENSG00000157106
    Entrez Gene
    23049
    UniGene
    460179
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SMG1
    GeneCards
    SMG1