Cell Senescence Entries for SMARCA4

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of BRG1 (SMARCA4) expression in mesenchymal stem cells induced a significant increase in senescent cells and a decrease in apoptotic cells. This was also accompanied by an increase in heterochromatin and activation of the retinoblastoma-like protein 2 (RB2)/P130- and P53-related pathways.
Primary Reference

    SMARCA4 Gene Information

    HGNC symbol
    SMARCA4 
    Aliases
    BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A 
    Common name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 
    Entrez Id
    6597
    Description
    The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

    SMARCA4 Ontologies

    Gene Ontology
    Process: GO:43044; ATP-dependent chromatin remodeling
    GO:1904837; beta-catenin-TCF complex assembly
    GO:6325; chromatin organization
    GO:6338; chromatin remodeling
    GO:16569; covalent chromatin modification
    GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
    GO:60766; negative regulation of androgen receptor signaling pathway
    GO:30308; negative regulation of cell growth
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:7070; negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle
    GO:45892; negative regulation of transcription, DNA-templated
    And 14 more GO terms
    Cellular component: GO:16514; SWI/SNF complex
    GO:5615; extracellular space
    GO:16020; membrane
    GO:71565; nBAF complex
    GO:71564; npBAF complex
    GO:790; nuclear chromatin
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    Function: GO:5524; ATP binding
    GO:70182; DNA polymerase binding
    GO:8094; DNA-dependent ATPase activity
    GO:1164; RNA polymerase I CORE element sequence-specific DNA binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:980; RNA polymerase II distal enhancer sequence-specific DNA binding
    GO:1105; RNA polymerase II transcription coactivator activity
    GO:30957; Tat protein binding
    GO:50681; androgen receptor binding
    GO:4386; helicase activity
    GO:70577; lysine-acetylated histone binding
    And 8 more GO terms
    Show all GO terms

    Homologs of SMARCA4 in Model Organisms

    Caenorhabditis elegans
    swsn-4
    Danio rerio
    smarca4
    Mus musculus
    Smarca4
    Rattus norvegicus
    Smarca4
    Schizosaccharomyces pombe
    snf22

    External links

    OMIM
    603254
    Ensembl
    ENSG00000127616
    Entrez Gene
    6597
    UniGene
    327527
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SMARCA4
    GeneCards
    SMARCA4