Cell Senescence Entries for SLC16A7

Cell Types
Gastric cancer, Colon cancer
Cell Lines
LoVo, HT29, HCT8, HCT116, SW480, DLD1, MKN45, MKN74
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of monocarboxylate transporter 2 (SLC16A7), a protein which is tumor-selectively expressed in human colorectal malignancies, induced mitochondrial dysfunction, cell-cycle arrest and senescence without additional cellular stress in colorectal cancer cell lines.
Primary Reference

    SLC16A7 Gene Information

    HGNC symbol
    SLC16A7 
    Aliases
    MCT2 
    Common name
    solute carrier family 16 member 7 
    Entrez Id
    9194
    Description
    This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

    SLC16A7 Ontologies

    Gene Ontology
    Process: GO:35873; lactate transmembrane transport
    GO:1901475; pyruvate transmembrane transport
    Cellular component: GO:5887; integral component of plasma membrane
    GO:5886; plasma membrane
    Function: GO:15129; lactate transmembrane transporter activity
    GO:8028; monocarboxylic acid transmembrane transporter activity
    GO:5477; pyruvate secondary active transmembrane transporter activity
    GO:50833; pyruvate transmembrane transporter activity
    GO:15293; symporter activity
    Show all GO terms

    Homologs of SLC16A7 in Model Organisms

    Danio rerio
    zgc:165507
    Mus musculus
    Slc16a7
    Rattus norvegicus
    Slc16a7

    External links

    OMIM
    603654
    Ensembl
    ENSG00000118596
    Entrez Gene
    9194
    UniGene
    88156
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SLC16A7
    GeneCards
    SLC16A7