Cell Senescence Entries for SLC16A7
- Cell Types
- Gastric cancer, Colon cancer
- Cell Lines
- LoVo, HT29, HCT8, HCT116, SW480, DLD1, MKN45, MKN74
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- Knockdown of monocarboxylate transporter 2 (SLC16A7), a protein which is tumor-selectively expressed in human colorectal malignancies, induced mitochondrial dysfunction, cell-cycle arrest and senescence without additional cellular stress in colorectal cancer cell lines.
- Primary Reference
SLC16A7 Gene Information
- HGNC symbol
- SLC16A7
- Aliases
- MCT2
- Common name
- solute carrier family 16 member 7
- Entrez Id
- 9194
- Description
- This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
SLC16A7 Ontologies
- Gene Ontology
-
Process: GO:35873; lactate transmembrane transport
GO:1901475; pyruvate transmembrane transport
Cellular component: GO:5887; integral component of plasma membrane
GO:5886; plasma membrane
Function: GO:15129; lactate transmembrane transporter activity
GO:8028; monocarboxylic acid transmembrane transporter activity
GO:5477; pyruvate secondary active transmembrane transporter activity
GO:50833; pyruvate transmembrane transporter activity
GO:15293; symporter activity
Homologs of SLC16A7 in Model Organisms
- Danio rerio
- zgc:165507
- Mus musculus
- Slc16a7
- Rattus norvegicus
- Slc16a7
External links
- OMIM
- 603654
- Ensembl
- ENSG00000118596
- Entrez Gene
- 9194
- UniGene
- 88156
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SLC16A7
- GeneCards
- SLC16A7