Cell Senescence Entries for SIRT6

Cell Types
Chondrocyte
Cell Lines
NHAC-kn
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
SIRT6 inhibition significantly reduced proliferation and increased SA-beta-galactosidase positive chondrocytes. SIRT6 inhibition also led to increased p16 levels. Immunofluorescence microscopy showed that gamma-H2AX foci and TIFs were increased by SIRT6 inhibition.
Primary Reference

    SIRT6 Gene Information

    HGNC symbol
    SIRT6 
    Aliases
    SIR2L6 
    Common name
    sirtuin 6 
    Entrez Id
    51548
    Description
    This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

    SIRT6 Ontologies

    Gene Ontology
    Process: GO:6284; base-excision repair
    GO:42593; glucose homeostasis
    GO:1990619; histone H3-K9 deacetylation
    GO:61647; histone H3-K9 modification
    GO:8285; negative regulation of cell proliferation
    GO:46325; negative regulation of glucose import
    GO:45820; negative regulation of glycolytic process
    GO:45892; negative regulation of transcription, DNA-templated
    GO:1905555; positive regulation blood vessel branching
    GO:1902732; positive regulation of chondrocyte proliferation
    GO:31940; positive regulation of chromatin silencing at telomere
    And 11 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5724; nuclear telomeric heterochromatin
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3956; NAD(P)+-protein-arginine ADP-ribosyltransferase activity
    GO:3950; NAD+ ADP-ribosyltransferase activity
    GO:70403; NAD+ binding
    GO:17136; NAD-dependent histone deacetylase activity
    GO:46969; NAD-dependent histone deacetylase activity (H3-K9 specific)
    GO:34979; NAD-dependent protein deacetylase activity
    GO:3682; chromatin binding
    GO:5515; protein binding
    GO:3714; transcription corepressor activity
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of SIRT6 in Model Organisms

    Caenorhabditis elegans
    sir-2.4
    Danio rerio
    sirt6
    Drosophila melanogaster
    Sirt6
    Mus musculus
    Sirt6
    Rattus norvegicus
    Sirt6

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Sirt6
    • A homolog of this gene for Drosophila melanogaster is present as Sirt6
    GenAge human genes
    • This gene is present as SIRT6
    LongevityMap
    • This gene is present as SIRT6

    External links

    OMIM
    606211
    Ensembl
    ENSG00000077463
    Entrez Gene
    51548
    UniGene
    423756
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SIRT6
    GeneCards
    SIRT6